NPFF1-R antagonist 1
Based on 1 Customer Validation
NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.38%
- CAS 番号: 3057753-40-6
- 分子式: C37H44N4O
- 分子量:560.77
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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NPFF1-R 211 ± 54 nM (Ki) |
NPFF2-R 3270 ±639 nM (Ki) |
κ Opioid Receptor/KOR 1390 ± 147 nM (Ki) |
δ Opioid Receptor/DOR 1540 ± 132 nM (Ki) |
μ Opioid Receptor/MOR 3560 ± 364 nM (Ki) |
体外実験
NPFF1-R antagonist 1 (compound 8b) shows some off target binding at the opioid receptors (DOR, KOR, and MOR), with Ki values of 1540 ± 132, 1390 ± 147, and 3560 ± 364 nM, respectively[1].
NPFF1-R antagonist 1 (0-10 μM) fails to inhibit cAMP stimulation, dose-dependently reverses NPFF inhibition of forskolin (HY-15371)-induced cAMP accumulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3057753-40-6
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性状 Solid
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分子量 560.77
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分子式 C37H44N4O
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Color White to off-white
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SMILES
O=C(CN1CCC(CC2=CC=CC=C2)CC1)NCC3(CCN(CC4=CC=CC=C4)CC3)NC5=C(C=CC=C6)C6=CC=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 4.29 mg/mL (7.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
ホットトピック
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Topics Neuropeptide: Connecting Nerves And Immunity
Neuropeptides are signaling molecules released by neurons that function at the interface of the nervous and immune systems and represent central mediators of neuroimmune communication.
2026-06-18
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7833 mL | 8.9163 mL | 17.8326 mL | 44.5816 mL |
| 5 mM | 0.3567 mL | 1.7833 mL | 3.5665 mL | 8.9163 mL |
NPFF1-R antagonist 1 関連分類
HY-161405 関連分類
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