NPFF1-R antagonist 1
Based on 1 Customer Validation
NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 3057753-40-6
- Formula: C37H44N4O
- Molecular Weight:560.77
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Opioid Receptor Isoforms
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Biological Activity
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NPFF1-R 211 ± 54 nM (Ki) |
NPFF2-R 3270 ±639 nM (Ki) |
κ Opioid Receptor/KOR 1390 ± 147 nM (Ki) |
δ Opioid Receptor/DOR 1540 ± 132 nM (Ki) |
μ Opioid Receptor/MOR 3560 ± 364 nM (Ki) |
NPFF1-R antagonist 1 (compound 8b) shows some off target binding at the opioid receptors (DOR, KOR, and MOR), with Ki values of 1540 ± 132, 1390 ± 147, and 3560 ± 364 nM, respectively[1].
NPFF1-R antagonist 1 (0-10 μM) fails to inhibit cAMP stimulation, dose-dependently reverses NPFF inhibition of forskolin (HY-15371)-induced cAMP accumulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3057753-40-6
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Appearance Solid
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Molecular Weight 560.77
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Formula C37H44N4O
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Color White to off-white
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SMILES
O=C(CN1CCC(CC2=CC=CC=C2)CC1)NCC3(CCN(CC4=CC=CC=C4)CC3)NC5=C(C=CC=C6)C6=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 4.29 mg/mL (7.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7833 mL | 8.9163 mL | 17.8326 mL | 44.5816 mL |
| 5 mM | 0.3567 mL | 1.7833 mL | 3.5665 mL | 8.9163 mL |
NPFF1-R antagonist 1 Related Classifications
HY-161405 Related Classifications
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