2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide FF Receptor Opioid Receptor
  4. NPFF1-R antagonist 1

NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.

For research use only. We do not sell to patients.

NPFF1-R antagonist 1 Chemical Structure

NPFF1-R antagonist 1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

NPFF1-R antagonist 1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively[1].

IC50 & Target

NPFF1-R

211 ± 54 nM (Ki)

NPFF2-R

3270 ±639 nM (Ki)

κ Opioid Receptor/KOR

1390 ± 147 nM (Ki)

δ Opioid Receptor/DOR

1540 ± 132 nM (Ki)

μ Opioid Receptor/MOR

3560 ± 364 nM (Ki)

In Vitro

NPFF1-R antagonist 1 (compound 8b) shows some off target binding at the opioid receptors (DOR, KOR, and MOR), with Ki values of 1540 ± 132, 1390 ± 147, and 3560 ± 364 nM, respectively[1].
NPFF1-R antagonist 1 (0-10 μM) fails to inhibit cAMP stimulation, dose-dependently reverses NPFF inhibition of forskolin (HY-15371)-induced cAMP accumulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NPFF1-R antagonist 1 Related Antibodies
Molecular Weight

560.77

Formula

C37H44N4O
SMILES

O=C(CN1CCC(CC2=CC=CC=C2)CC1)NCC3(CCN(CC4=CC=CC=C4)CC3)NC5=C(C=CC=C6)C6=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

NPFF1-R antagonist 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPFF1-R antagonist 1Neuropeptide FF ReceptorOpioid ReceptorCHO cellsNPFFcAMPInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NPFF1-R antagonist 1
Cat. No.:
HY-161405
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.