[Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA

Name: [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA
Brand: MedChemExpress
SKU: HY-P1323A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1323A Purity: 98.07%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

For research use only. We do not sell to patients.

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[Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA:

[Leu31,Pro34]-Neuropeptide Y (human,rat) Get quote

1 Publications Citing Use of MCE [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA

•J Headache Pain. 2023 May 25;24(1):61. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

NPY Y₁ receptor

NPY Y₄ receptor

NPY Y₅ receptor

In Vitro

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has K_i values of 0.39 nM, 0.499 nM, 0.31 nM for Y₁, Y₄, Y₅ in HEK cell lines. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has a K_i of >1000 for Y₂ in HEK cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

4354.76

Formula

C₁₉₁H₂₈₅F₃N₅₄O₅₈S

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (11.48 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2296 mL	1.1482 mL	2.2963 mL
5 mM	0.0459 mL	0.2296 mL	0.4593 mL
10 mM	0.0230 mL	0.1148 mL	0.2296 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.07%

Select Batch:

Data Sheet (287 KB) SDS (252 KB)

COA (240 KB) RP-HPLC (135 KB) MS (77 KB)

Handling Instructions (2659 KB)

References

[1]. K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y₅-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58. [Content Brief]

[2]. J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y₁ receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. [Content Brief]

[3]. A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.2296 mL	1.1482 mL	2.2963 mL	5.7408 mL
	5 mM	0.0459 mL	0.2296 mL	0.4593 mL	1.1482 mL
	10 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5741 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.