1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. [D-Trp34]-Neuropeptide Y

[D-Trp34]-Neuropeptide Y 

Cat. No.: HY-P1322
Handling Instructions

[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Trp34]-Neuropeptide Y Chemical Structure

[D-Trp34]-Neuropeptide Y Chemical Structure

CAS No. : 153549-84-9

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Description

[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats[1][2].

IC50 & Target[1]

NPY Y5 receptor

 

In Vitro

[D-Trp34]-Neuropeptide Y has pKi values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5 in CHO cells. [D-Trp34]-Neuropeptide Y has pEC50 values of 6.44, <6, 6.28,7.82 for rY1, rY2 in CHO cells and rY4, rY5 in HEK-293 cells[1].

In Vivo

[D-Trp34]-Neuropeptide Y (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].

Molecular Weight

2352.74

Formula

C₁₁₀H₁₇₀N₃₄O₂₄

CAS No.

153549-84-9

Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

[D-Trp34]-Neuropeptide YNeuropeptide Y ReceptorNPY receptorY1Y2Y4y6foodintakeInhibitorinhibitorinhibit

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Product Name:
[D-Trp34]-Neuropeptide Y
Cat. No.:
HY-P1322
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