1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. BIBO3304 TFA

BIBO3304 TFA 

Cat. No.: HY-107725
Handling Instructions

BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).

For research use only. We do not sell to patients.

BIBO3304 TFA Chemical Structure

BIBO3304 TFA Chemical Structure

CAS No. : 191868-14-1

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Description

BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively)[1].

In Vivo

BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting[1].
BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY[1].
BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Chbb:Thom rats weighing between 300 and 340 g[1]
Dosage: 30 μg
Administration: bilateral paraventricular nucleus injection
Result: Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.
Animal Model: 7-week-old C57BL/6JAusb mice[2]
Dosage: 0.5 μM
Administration: p.o.
Result: Significantly increased serum insulin levels.
Molecular Weight

643.66

Formula

C₃₁H₃₆F₃N₇O₅

CAS No.

191868-14-1

SMILES

O=C(N[[email protected]@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BIBO3304BIBO 3304BIBO-3304Neuropeptide Y ReceptorNPY receptororalsubtypeseruminsulinhyperphagiarefeedingInhibitorinhibitorinhibit

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BIBO3304 TFA
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