1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. RTI-118

RTI-118 

Cat. No.: HY-111308
Handling Instructions

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration.

For research use only. We do not sell to patients.

RTI-118 Chemical Structure

RTI-118 Chemical Structure

CAS No. : 847554-50-1

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Description

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration[1].

In Vitro

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant[2].

In Vivo

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg)[1].

Animal Model: Rat[1]
Dosage: 5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration: Intraperitoneal injection; pre-treatment 30 minutes; 5-30 mg/kg
Result: The effects on the reinstatement of extinguished cocaine-seeking behavior are restricted to doses of 20 mg/kg or less.
Molecular Weight

448.56

Formula

C₂₆H₃₂N₄O₃

CAS No.

847554-50-1

SMILES

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCCN5CCCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RTI-118RTI118RTI 118Neuropeptide Y ReceptorNPY receptorcocaineself-administrationNPSRdrugaddictionInhibitorinhibitorinhibit

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RTI-118
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HY-111308
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