2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. RTI-118

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration.

For research use only. We do not sell to patients.

RTI-118 Chemical Structure

RTI-118 Chemical Structure

CAS No. : 847554-50-1

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RTI-118 Related Antibodies

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Description

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration[1].

In Vitro

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RTI-118 Related Antibodies
In Vivo

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in food self-administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration: Intraperitoneal injection; pre-treatment 30 minutes; 5-30 mg/kg
Result: The effects on the reinstatement of seeking behavior are restricted to doses of 20 mg/kg or less.
Molecular Weight

448.56

Formula

C26H32N4O3
CAS No.
SMILES

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCCN5CCCCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RTI-118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RTI-118847554-50-1RTI118RTI 118Neuropeptide Y ReceptorNPY receptorself-administrationNPSRdrugaddictionInhibitorinhibitorinhibit

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HY-111308
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