Maltodextrin, dextrose equivalent 5.0-8.0 

Maltodextrin, dextrose equivalent 5.0-8.0 can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs^[1].

Maltodextrin, dextrose equivalent 5.0-8.0 is a polysaccharide with good biocompatibility and drug encapsulation ability, that encapsulates BSA as a model protein with an efficiency of about 70% and a loading rate of up to 20%. Maltodextrin, dextrose equivalent 5.0-8.0 exhibits non-toxic to cells at a concentrations of 5 mg/mL, and can be used in drug delivery system. The glucose equivalent (DE) value reflects the degree of hydrolysis of maltodextrin. The higher the DE value, the higher the degree of hydrolysis is. Maltodextrin, dextrose equivalent 5.0-8.0 forms stable nanoparticles with particle sizes ranging from 170 nm to 450 nm and a narrow particle size distribution^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₆H₁₀O₅)n·xH₂O

9050-36-6

Solid

White to off-white

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H](COC)O[C@H](O[H])[C@H](O)[C@H]2O)O1.[y].[x]

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

• [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [2]. Takeiti, C. Y., et al. Morphological and Physicochemical Characterization of Commercial Maltodextrins with Different Degrees of Dextrose-Equivalent. International Journal of Food Properties, 13(2), 411–425.