2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MC-Val-Cit-PAB-MMAF

MC-Val-Cit-PAB-MMAF  (Synonyms: Vc-MMAF)

製品番号: HY-112786 純度: 99.25%
COA 取扱説明書 Technical Support

MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity.

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CAS 番号 : 863971-17-9

容量 価格（税別） 在庫状況 数量
1 mg $250 在庫あり
5 mg $506 在庫あり
10 mg $811 在庫あり
25 mg $1460 在庫あり
50 mg $2110 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 5 publication(s) in Google Scholar

MC-Val-Cit-PAB-MMAF 関連抗体

Top Publications Citing Use of Products

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    MC-Val-Cit-PAB-MMAF (ADC-MMAF) (50 nM; 72 h) effectively killed A375 WT cells.

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    Cytotoxicity assay on melanoma A375 WT cancer cell lines incubated with MC-Val-Cit-PAB-MMAF (ADC-MMAF) (0-1200 nM).

    MC-Val-Cit-PAB-MMAF purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 24;17(1):162.  [Abstract]

    MC-Val-Cit-PAB-MMAF (ADC-MMAF) (3.7 mg/kg; i.v.) was well tolerated in terms of weight changes of melanoma A375-bearing mice.

    Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1].

    IC50 & Target[1]

    Auristatin

     

    体外実験

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MC-Val-Cit-PAB-MMAF 関連抗体
    分子量

    1330.61

    分子式

    C68H103N11O16
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3)=O)=O)=O)=O)OC)=O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, stored under nitrogen

    *The compound is unstable in solutions, freshly prepared is recommended.
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (75.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.7515 mL 3.7577 mL 7.5153 mL
    5 mM 0.1503 mL 0.7515 mL 1.5031 mL
    10 mM 0.0752 mL 0.3758 mL 0.7515 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.25%

    COA (247 KB) HNMR (389 KB) RP-HPLC (140 KB) LCMS (153 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.7515 mL 3.7577 mL 7.5154 mL 18.7884 mL
    5 mM 0.1503 mL 0.7515 mL 1.5031 mL 3.7577 mL
    10 mM 0.0752 mL 0.3758 mL 0.7515 mL 1.8788 mL
    15 mM 0.0501 mL 0.2505 mL 0.5010 mL 1.2526 mL
    20 mM 0.0376 mL 0.1879 mL 0.3758 mL 0.9394 mL
    25 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
    30 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6263 mL
    40 mM 0.0188 mL 0.0939 mL 0.1879 mL 0.4697 mL
    50 mM 0.0150 mL 0.0752 mL 0.1503 mL 0.3758 mL
    60 mM 0.0125 mL 0.0626 mL 0.1253 mL 0.3131 mL
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    MC-Val-Cit-PAB-MMAF Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MC-Val-Cit-PAB-MMAF863971-17-9Vc-MMAFDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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    製品名:
    MC-Val-Cit-PAB-MMAF
    製品番号:
    HY-112786
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