2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MCC

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1.

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MCC

MCC 화학구조

CAS No. : 104676-09-7

사이즈 가격 재고 수량
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg   견적 받기  
1 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

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MCC Related Antibodies

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  • 순도&문서

  • References

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제품 설명

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1].

In Vitro

Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCC Related Antibodies
Clinical Trial
분자량

236.27

화학식

C12H16N2O3
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C=CC1=O)N1CC2CCC(C(N)=O)CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도
In Vitro: 

DMSO : 100 mg/mL (423.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2324 mL 21.1621 mL 42.3243 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2324 mL 21.1621 mL 42.3243 mL 105.8107 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL 21.1621 mL
10 mM 0.4232 mL 2.1162 mL 4.2324 mL 10.5811 mL
15 mM 0.2822 mL 1.4108 mL 2.8216 mL 7.0540 mL
20 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2905 mL
25 mM 0.1693 mL 0.8465 mL 1.6930 mL 4.2324 mL
30 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5270 mL
40 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
50 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1162 mL
60 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
80 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3226 mL
100 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
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MCC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCC104676-09-7ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Inquiry Information

상품명:
MCC
Cat. No.:
HY-132251
수량:
MCE Japan Authorized Agent:

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