2. Academic Validation
  3. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. doi: 10.1016/s0960-894x(00)00014-7.
C K Ryu 1,  H Y Kang,  S K Lee,  K A Nam,  C Y Hong,  W G Ko,  B H Lee
Affiliations

Affiliation

PMID: 10743948 DOI: 10.1016/s0960-894x(00)00014-7
Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human Cancer cell lines.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-100624
    CDK Inhibitor
    CDK