1. Cell Cycle/DNA Damage
  2. CDK
  3. Ryuvidine

Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells.

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Ryuvidine Chemical Structure

Ryuvidine Chemical Structure

CAS No. : 265312-55-8

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Description

Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro[1]. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells[2].

IC50 & Target

CDK4

6.0 μM (IC50)

Molecular Weight

284.33

Formula

C15H12N2O2S

CAS No.
SMILES

O=C1C=C(C(C2=C1SC(C)=N2)=O)NC3=CC=C(C)C=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Ryuvidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Ryuvidine
Cat. No.:
HY-100624
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