5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. doi: 10.1016/s0960-894x(00)00014-7.
C K Ryu  1 ,  H Y Kang ,  S K Lee ,  K A Nam ,  C Y Hong ,  W G Ko ,  B H Lee
Affiliations
PMID: 10743948 DOI: 10.1016/s0960-894x(00)00014-7
Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human Cancer cell lines.

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