2. Academic Validation
  3. New 3,4-Secocycloartane and 3,4-Secodammarane Triterpenes from the Ecuadorian Plant Coussarea macrophylla

New 3,4-Secocycloartane and 3,4-Secodammarane Triterpenes from the Ecuadorian Plant Coussarea macrophylla

  • Chem Biodivers. 2015 Jun;12(6):946-54. doi: 10.1002/cbdv.201400182.
Gianluca Gilardoni 1,  Ximena Chiriboga 2,  Paola Vita Finzi 1,  Giovanni Vidari 3
Affiliations

Affiliations

  • 1 Università degli Studi di Pavia, Dipartimento di Chimica and CISTRE, V.le Taramelli 12, IT-27100 Pavia (phone: +39 0382987322; fax: +39 0382987323).
  • 2 Universidad Central del Ecuador, Escuela de Bioquimica y Farmacia, Facultad de Ciencias Quimicas, Quito, Ecuador.
  • 3 Università degli Studi di Pavia, Dipartimento di Chimica and CISTRE, V.le Taramelli 12, IT-27100 Pavia (phone: +39 0382987322; fax: +39 0382987323). [email protected].
PMID: 26080740 DOI: 10.1002/cbdv.201400182
Abstract

Coussarea macrophylla (Mart.) Müll.Arg. (Rubiaceae) was collected in Ecuador, and the bark was extracted with AcOEt. Chromatographic separation afforded six novel 3,4-secocycloartane and 3,4-secodammarane Triterpenes, named macrocoussaric acids A-F, together with the known metabolites secaubryenol and 3,4-secodammara-4(28),20,24-triene-3,26-dioic acid. The structures of the new compounds were determined on the basis of their spectroscopic data. This is the first report of 3,4-secocycloartane and 3,4-secodammarane Triterpenes occurring in a Coussarea species. Macrocoussaric acids A and B (2 and 3, resp.) were found to be moderately cytotoxic against five different tumor cell lines.

Keywords

Coussarea macrophylla; Macrocoussaric acids A - F; Secocycloartane triterpenes; Secodammarane triterpenes; Triterpenes.

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