1. Academic Validation
  2. Broad-spectrum antiviral properties of andrographolide

Broad-spectrum antiviral properties of andrographolide

  • Arch Virol. 2017 Mar;162(3):611-623. doi: 10.1007/s00705-016-3166-3.
Swati Gupta 1 K P Mishra 2 Lilly Ganju 1
Affiliations

Affiliations

  • 1 Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
  • 2 Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. [email protected].
Abstract

Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various Plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers Antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent Antiviral drug with multiple effects.

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