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Cat. No.: HY-N0191A

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14-epi-Andrographolide

(Synonyms: 14-Epiandrographolide)

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14-epi-andrographolide is a diterpene analog of Andrographolide (HY-N0191), which is an NF-κB inhibitor and antiviral agent.

For research use only. We do not sell to patients.

Purity: 95.0%
CAS No.: 142037-79-4
Formula: C₂₀H₃₀O₅
Molecular Weight:350.45

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

14-epi-Andrographolide Chemical Structure

CAS No.: 142037-79-4

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

14-epi-andrographolide is a diterpene analog of Andrographolide (HY-N0191), which is an NF-κB inhibitor and antiviral agent^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	26.51 μM Compound: 22	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 22264489]

Chemical Information

CAS No. 142037-79-4
Appearance Solid
Molecular Weight 350.45
Formula C₂₀H₃₀O₅
Color White to off-white
SMILES

C[C@]12[C@@](CCC([C@H]2C/C=C3[C@H](COC\3=O)O)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Synonyms

14-Epiandrographolide
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Acanthaceae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. MATSUDA T, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees[J]. Chemical and Pharmaceutical Bulletin, 1994, 42(6): 1216-1225.

[2]. Zhai ZJ, et al. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171(3):663-75. [Content Brief]

[3]. Gupta S, et al. Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017 Mar;162(3):611-623. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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