142037-79-4
142037-79-4
Chemical Structure
14-epi-Andrographolide
Synonym(s): 14-Epiandrographolide
- CAS. Nr.: 142037-79-4
- Formula:C20H30O5
- Molecular Weight:350.45
IUPAC Name: (R,E)-4-hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one
InChIKey: BOJKULTULYSRAS-NPWGMBKGSA-N
SMILES: C[C@]12[C@@](CCC([C@H]2C/C=C3[C@H](COC\3=O)O)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Biological Activity: 14-epi-andrographolide is a diterpene analog of Andrographolide (HY-N0191), which is an NF-κB inhibitor and antiviral agent[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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14-epi-Andrographolide | 95.0% | 14-epi-andrographolide is a diterpene analog of Andrographolide (HY-N0191), which is an NF-κB inhibitor and antiviral agent. | ||||||||||||||||||||
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References
- [1]. MATSUDA T, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees[J]. Chemical and Pharmaceutical Bulletin, 1994, 42(6): 1216-1225.
- [2]. Zhai ZJ, et al. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171(3):663-75. [Content Brief]
- [3]. Gupta S, et al. Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017 Mar;162(3):611-623. [Content Brief]
