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  3. The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

  • Plants (Basel). 2021 Jan 11;10(1):132. doi: 10.3390/plants10010132.
Nilufar Z Z Mamadalieva 1 2,  Davlat Kh Kh Akramov 1,  Ludger A A Wessjohann 2,  Hidayat Hussain 2,  Chunlin Long 3 4,  Komiljon Sh Sh Tojibaev 5,  Elham Alshammari 6,  Mohamed L L Ashour 7 8,  Michael Wink 9
Affiliations

Affiliations

  • 1 Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan.
  • 2 Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany.
  • 3 College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.
  • 4 Key Laboratory of Ethnomedicine, Ministry of Education, Minzu University of China, Beijing 100081, China.
  • 5 Institute of Botany of the Academy Sciences of Uzbekistan, Durmon Yuli Str 32, Tashkent 100125, Uzbekistan.
  • 6 Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
  • 7 Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
  • 8 Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
  • 9 Department of Pharmaceutical Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.
PMID: 33440727 DOI: 10.3390/plants10010132
Abstract

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, Flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, Lignans, Steroids, Alkaloids, Polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, Minerals, Vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, Antibacterial, anti-inflammatory, anti-allergic, cytotoxic, Enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

Keywords

Lagochilus; Lamiaceae; biological properties; diversity; pharmacology; phytochemistry; secondary metabolites; traditional medicine.

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