2. Academic Validation
  3. In Situ biomimetic Nanoformulation for metastatic cancer immunotherapy

In Situ biomimetic Nanoformulation for metastatic cancer immunotherapy

  • Acta Biomater. 2021 Oct 15:134:633-648. doi: 10.1016/j.actbio.2021.07.055.
Xuan Zhang 1,  Yan Zhang 2,  Haiping Zheng 3,  Yufeng He 4,  Honglin Jia 4,  Liyuan Zhang 1,  Chunjie Lin 5,  Shuang Chen 2,  Junfeng Zheng 1,  Qunfang Yang 1,  Tao Liu 1,  Xichun Pan 1,  Haigang Zhang 1,  Chenhui Wang 6,  Lei Ren 7,  Wenjun Shan 8
Affiliations

Affiliations

  • 1 Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, P.R. China.
  • 2 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P.R. China.
  • 3 School of Medicine, Xiamen University, Xiamen, 361102, P.R. China.
  • 4 Department of Dermatology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, P.R. China.
  • 5 School of Life Sciences, Xiamen University, Xiamen, 361102, P.R. China.
  • 6 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P.R. China. Electronic address: [email protected].
  • 7 Department of Biomaterials, State Key Lab of Physical Chemistry of Solid Surface, College of Materials, Xiamen University, Xiamen 361005, P.R. China. Electronic address: [email protected].
  • 8 Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, P.R. China. Electronic address: [email protected].
PMID: 34329780 DOI: 10.1016/j.actbio.2021.07.055
Abstract

Metastasis is the leading cause of death in Cancer patients. Eliciting anti-tumor immune responses against lung metastasis is hindered by the immunosuppressive microenvironment. This study explored a biomimetic nanoformulation, comprising a nanovaccine (OP) that delivers tumor antigens and adjuvants spatially and temporally in a virus-like manner, and a pulmonary surfactant-biomimetic Liposome with an immunomodulator, JQ1 (PS-JQ1). The findings of this study showed that intratracheal administration of OP+PS-JQ1 activated lung immune cells without concomitant excess inflammation, enhanced tumor antigen cross-presentation, generated a significantly high antigen-specific CD8+ T cell response, and reshaped the immunocellular composition in B16 melanoma tumor-bearing lung. OP+PS-JQ1 nanoformulation exhibited a striking immunotherapeutic efficacy, induced local and systemic tumor suppression, improved survival of mice, initiated immune memory that prevents recurrence of secondary tumors. This stable and nontoxic nanoformulation provides a simple, flexible, and robust strategy for augmenting anti-tumor immunity for metastatic Cancer. STATEMENT OF SIGNIFICANCE: Egg glue proteins are produced by female insects, which can make the eggs firmly attached to the oviposition sites, not affected by wind and rain. However, genes encoding insect egg glue proteins have not yet been reported, and the molecular mechanism underpinning their adhesion is still unknown. Our study makes a significant contribution to the literature as it identifies the sequence, structure, adhesive property, and mechanism of silkworm egg glue protein. Furthermore, it outlines key insights into the structure-function relationships associated with egg glue proteins. We believe that this paper will be of interest to the readership of your journal as it identifies the first complete sequence of insect egg glue proteins, thereby highlighting their potentials future applications in both the biomedical and technical fields.

Keywords

Biomimetic; Iimmunotherapy; Lung metastasis; Nanoformulation.

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