2. Academic Validation
  3. Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells

Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells

  • Biochem Biophys Res Commun. 2021 Dec 17:583:184-191. doi: 10.1016/j.bbrc.2021.10.067.
Yan Li 1,  Panpan Wang 2,  Zhuoling Zou 1,  Qi Pan 1,  Xiaoyun Li 3,  Zien Liang 1,  Lingyu Li 4,  Yingbing Lin 1,  Xueyu Peng 1,  Ronghua Zhang 5,  Huaqin Tian 6,  Li Han 7
Affiliations

Affiliations

  • 1 College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China.
  • 2 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China; Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China.
  • 3 Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China; College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510630, PR China.
  • 4 Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China; Cancer Research Institute, Jinan University, Guangzhou, Guangdong, 510630, PR China.
  • 5 Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China; College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510630, PR China. Electronic address: [email protected].
  • 6 Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, 528000, PR China. Electronic address: [email protected].
  • 7 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China. Electronic address: [email protected].
PMID: 34749235 DOI: 10.1016/j.bbrc.2021.10.067
Abstract

Triple-negative breast Cancer (TNBC) lacks a recognized therapeutic molecular target and has an unfavorable prognosis. (20S)-Protopanaxatriol (g-PPT, PPT) is an active metabolite extracted from ginseng. Accumulating evidence suggests that it has good anti-cancer activity in vivo and in vitro. In this study, we aimed to elucidate the anti-tumor effects of PPT in TNBC cells and tumor-bearing mice, as well as the relevant molecular mechanisms of Autophagy and Apoptosis. In vitro, we have found that PPT is capable of inducing non-protective Autophagy and Apoptosis, thus exerting some anti-proliferative and anti-migration activity in TNBC cells. And in vivo, the therapeutic effects of PPT were evaluated by xenograft mouse models. The potential binding mode of PPT and Akt was predicted by molecular docking. Our findings indicated that PPT treatment induced non-protective Autophagy in TNBC cells by inhibiting the Akt/mTOR signaling pathway. Therefore, PPT may be a potential treatment for TNBC in the future.

Keywords

(20S)-Protopanaxatriol; Akt/mTOR signaling pathway; Apoptosis; Autophagy; Triple negative breast cancer (TNBC).

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