2. Academic Validation
  3. Antiulcerogenic and healing activity of hecogenin acetate in rodents

Antiulcerogenic and healing activity of hecogenin acetate in rodents

  • Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr;396(4):759-769. doi: 10.1007/s00210-022-02341-0.
Aline Jeane Costa Sousa 1,  Benedito Pereira de Sousa Neto 1,  Douglas Soares da Costa 1,  Maisa Campelo de Sousa 1,  Camila Ernanda Sousa de Carvalho 1,  Lucindo José Quintans-Junior 2,  Jullyana Souza Siqueira Quintans 2,  Josyanne Araujo Neves 3,  Francilene Vieira da Silva 4,  Ana Flávia Seraine Custódio Viana 1,  Paulo Humberto Moreira Nunes 1,  Rita de Cássia Meneses Oliveira 5
Affiliations

Affiliations

  • 1 Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil.
  • 2 Federal University of Sergipe, Marechal Rondom Avenue, S/N CEP 49.000-100, São Cristóvão, Sergipe, Brazil.
  • 3 Federal Institute of Education, Science and Technology of Maranhão, Colares Moreira Avenue, 477 - Jardim Renascença, Codó, Maranhão, Brazil.
  • 4 State University of Maranhão, Morro Do Alecrim, s/n CEP 65.600-000, Maranhão, Caxias, Brazil.
  • 5 Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil. [email protected].
PMID: 36474020 DOI: 10.1007/s00210-022-02341-0
Abstract

Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion, bicarbonate production, adequate blood flow) and harmful factors (excess pepsin or hydrochloric acid). Some drugs used in peptic ulcer therapy are associated with adverse effects. The aim of this study was to evaluate the antiulcerogenic and healing activity of hecogenin acetate (HA) in acute and chronic models of gastric lesions in rodents. The antiulcerogenic activity of HA was evaluated in models of gastric lesions induced by absolute ethanol and in acidified ethanol with HA (5, 10, and 20 mg/kg). For the model of gastric lesions induced by ischemia and reperfusion, rats were pre-treated with HA (5, 10, 20 mg/kg). After that, they were submitted to 30 min of ischemia, followed by 1 h of reperfusion. To evaluate the healing activity was induced gastric ulcer using acetic acid (80%) in rats. After 24 h, they were treated for 7 consecutive days with HA (10 and 20 mg/kg). They were evaluated the possible signs of toxicity, measurement of the lesions, Collagen deposition, and histological analysis. HA significantly reduced the area of the lesion in models of gastric lesions induced by absolute and acidified ethanol, ischemia-induced gastric lesions and reperfusion, and regarding healing. In the Collagen deposition, the presence and increase of Collagen demonstrate the healing effect. The AH has antiulcerogenic and healing potential demonstrated by the decrease in gastric injury and presence of Collagen fibers, respectively.

Keywords

Collagen; Gastroprotection; Hecogenin; Saponins; Ulcer.

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