2. Academic Validation
  3. Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway

Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway

  • Pharmaceuticals (Basel). 2023 Jan 1;16(1):70. doi: 10.3390/ph16010070.
Xi Wang 1,  Gang Shao 1 2,  Xiangyu Hong 2,  Yue Shi 2,  Yiting Zheng 2,  Yucheng Yu 2,  Caiyun Fu 2 3
Affiliations

Affiliations

  • 1 Department of Oncology, No.903 Hospital of PLA Joint Logistic Support Force, Hangzhou 310013, China.
  • 2 Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
  • 3 Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, China.
PMID: 36678567 DOI: 10.3390/ph16010070
Abstract

Colon Cancer is one of the most common digestive tract malignancies, having the second highest mortality rate among all tumors, with a five-year survival of advanced patients of only 10%. Efficient, targeted drugs are still lacking in treating colon Cancer, so it is urgent to explore novel druggable targets. Here, we demonstrated that annexin A1 (ANXA1) was overexpressed in tumors of 50% of colon Cancer patients, and ANXA1 overexpression was significantly negatively correlated with the poor prognosis of colon Cancer. ANXA1 promoted the abnormal proliferation of colon Cancer cells in vitro and in vivo by regulating the cell cycle, while the knockdown of ANXA1 almost totally inhibited the growth of colon Cancer cells in vivo. Furthermore, ANXA1 antagonized the autophagic death of honokiol in colon Cancer cells via stabilizing mitochondrial Reactive Oxygen Species. Based on these results, we speculated that ANXA1 might be a druggable target to control colon Cancer and overcome drug resistance.

Keywords

annexin A1; autophagy; colon cancer; drug resistance; honokiol; hyperproliferation; reactive oxygen species.

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