1. Academic Validation
  2. Dismantlable Coronated Nanoparticles for Coupling the Induction and Perception of Immunogenic Cell Death

Dismantlable Coronated Nanoparticles for Coupling the Induction and Perception of Immunogenic Cell Death

  • Adv Mater. 2024 Apr 21:e2313097. doi: 10.1002/adma.202313097.
Huan Liang 1 Chunchen Xu 1 Daoxia Guo 1 Fei Peng 2 Nan Chen 2 Haiyun Song 1 Xiaoyuan Ji 1


  • 1 School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • 2 College of Chemistry and Materials Science, The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, 200234, China.

Therapy-induced immunogenic cell death (ICD) can initiate both innate and adaptive immune responses for amplified anti-tumor efficacy. However, dying cell-released ICD signals are prone to being sequestered by the TIM-3 receptors on dendritic cell (DC) surfaces, preventing immune surveillance. Herein, dismantlable coronated nanoparticles (NPs) are fabricated as a type of spatiotemporally controlled nanocarriers for coupling tumor cell-mediated ICD induction to DC-mediated immune sensing. These NPs are loaded with an ICD inducer, mitoxantrone (MTO), and wrapped by a redox-labile anti-TIM-3 (αTIM-3) antibody corona, forming a separable core-shell structure. The antibody corona disintegrates under high levels of extracellular Reactive Oxygen Species in the tumor microenvironment, exposing the MTO-loaded NP core for ICD induction and releasing functional αTIM-3 molecules for DC sensitization. Systemic administration of the coronated NPs augments DC maturation, promotes cytotoxic T cell recruitment, enhances tumor susceptibility to immune checkpoint blockade, and prevents the side effects of MTO. This study develops a promising nanoplatform to unleash the potential of host immunity in Cancer therapy.


TIM‐3; antibody corona; immune perception; immunogenic cell death; size shrinkable nanoparticles.