2. Academic Validation
  3. Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity

Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity

  • J Pharmacol Sci. 2025 Dec;159(4):279-282. doi: 10.1016/j.jphs.2025.09.010.
Yusuke Mori 1,  Keisuke Mine 2,  Takehiro Kawashiri 3,  Yusuke Koura 1,  Mami Ueda 1,  Risa Kaneko 1,  Shunsuke Fujita 1,  Akito Tsuruta 4,  Satoru Koyanagi 4,  Daisuke Kobayashi 1
Affiliations

Affiliations

  • 1 Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • 2 Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
  • 3 Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address: [email protected].
  • 4 Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
PMID: 41241438 DOI: 10.1016/j.jphs.2025.09.010
Abstract

Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a Proton Pump Inhibitor (PPI), exerts preventive effects against OIPN. In this study, we evaluated whether Other PPIs exert similar effects via in vitro and in vivo experiments. Notably, esomeprazole, lansoprazole, and rabeprazole, classified as PPIs, prevented oxaliplatin-induced cultured F11 neuronal cell damage, and repeated PPI administration prevented mechanical allodynia in rats. However, vonoprazan, a potassium ion-competitive acid blocker, did not exert such effects. Overall, our results highlight the class effects of PPIs against OIPN.

Keywords

Oxaliplatin; Peripheral neurotoxicity; Proton pump inhibitor.

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