2. Academic Validation
  3. High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation

High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation

  • JID Innov. 2026 Jan 19;6(2):100451. doi: 10.1016/j.xjidi.2026.100451.
Mengyan Hu 1,  Han Cao 1,  Li Zhang 1,  Yuhan Xia 1,  Jiayi Zhang 1,  Feng Xue 1,  Xia Li 1,  Jie Zheng 1
Affiliations

Affiliation

  • 1 Department of Dermatology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
PMID: 41716629 DOI: 10.1016/j.xjidi.2026.100451
Abstract

Epidermal keratinocytes are important for maintaining the skin barrier by interacting with immune cells and environmental stimuli. In this study, we reveal that a high-salt diet aggravated imiquimod-induced skin inflammation in a psoriasis-like mouse model, characterized by activation of the CCL20-CCR6 axis and increased infiltration of CCR6+ γδT cells in skin lesions. In the presence of additional sodium, the mRNA expression of Ccl20 was upregulated in keratinocytes, mediated by JNK/p38-SGK1 pathway. Consistent with our experimental findings, a positive correlation between SGK1 and CCL20 gene expression was also observed in the skin of patients with psoriasis. Taken together, these data demonstrated that a high-salt diet aggravated skin inflammation in a psoriasis-like mouse model through further activation of the CCL20‒CCR6 axis.

Keywords

IL-17A; Keratinocyte; NaCl; Sodium; T cell.

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