2. Anti-infection
  3. SARS-CoV Virus Protease
  4. mCMX110

mCMX110 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 35 nM. mCMX110 inhibits SARS-CoV-2 infection. SARS-CoV-2 mCMX110 can be used for the research of SARS-CoV-2 infection.

For research use only. We do not sell to patients.

mCMX110

mCMX110 Chemical Structure

CAS No. : 2883773-06-4

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mCMX110 Related Antibodies

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Description

mCMX110 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 35 nM. mCMX110 inhibits SARS-CoV-2 infection. SARS-CoV-2 mCMX110 can be used for the research of SARS-CoV-2 infection[1].

In Vitro

mCMX110 inhibits wild-type SARS-CoV-2 infection in HeLa-ACE2 cells with an EC50 of 97 nM, EC90 of 241 nM, and LLE_EC90 of 6.8, with no cytotoxicity at concentrations >40 μM[1].
mCMX110 inhibits Alpha variant SARS-CoV-2 infection in HeLa-ACE2 cells with an EC90 of 339 nM and Omicron variant SARS-CoV-2 infection with an EC90 of 255 nM[1].
mCMX110 (48 h) inhibits HCoV-OC43 infection in HCT-8 cells with an EC90 of 5.63 μM, with no cytotoxicity at concentrations >30 μM[1].
mCMX110 (120 h) inhibits HCoV-229E infection in MRC-5 pd25 cells with an EC90 of 930 nM, with no cytotoxicity at concentrations >30 μM[1].
mCMX110 does not inhibit CYP isoforms 1A2, 2C19, 2C9, 2D6, or 3A4 at concentrations >50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

mCMX110 Related Antibodies
In Vivo

mCMX110 (10-300 mg/kg; p.o.; single dose, or twice daily for 5 days) exhibits favorable oral bioavailability, and is well-tolerated in mice, rats, dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice; Sprague-Dawley rats; beagle dogs[1]
Dosage: 30, 50 mg/kg (CD1 mice, single dose); 30 mg/kg (Sprague-Dawley rats, single dose); 300 mg/kg (Sprague-Dawley rats, twice daily); 10, 100 mg/kg (beagle dogs, single dose); 250 mg/kg (beagle dogs, twice daily); 125 mg/kg/dose (beagle dogs, twice daily for 5 days); 100-300 mg/kg/dose (Sprague-Dawley rats, twice daily for 5 days)
Administration: p.o.; single dose; twice daily; twice daily for 5 days
Result: Reached oral bioavailability of 18% in CD1 mice, 10-12% in Sprague-Dawley rats, and 44-79% in beagle dogs.
Achieved plasma clearance (IV) of 83.7 mL/min/kg in CD1 mice, 15.3 mL/min/kg in Sprague-Dawley rats, 17.2 mL/min/kg in beagle dogs, and 32.6 mL/min/kg in cynomolgus monkeys.
Attained volume of distribution (IV, Vss) of 0.78 L/kg in CD1 mice, 1.3 L/kg in Sprague-Dawley rats, 0.93 L/kg in beagle dogs, and 1.5 L/kg in cynomolgus monkeys.
Exceeded the SARS-CoV-2 EC90 threshold (110 ng/mL) in plasma concentrations after oral dosing across all tested species, with good dose-proportional exposure in rats and dogs.
Caused no adverse effects in beagle dogs dosed at 125 mg/kg/dose twice daily for 5 days.
Showed no prohibitive findings in Sprague-Dawley rats dosed at 100-300 mg/kg/dose twice daily for 5 days.
Molecular Weight

454.56

Formula

C22H38N4O6
CAS No.
SMILES

O=C(NC(C)(C)C)C(N[C@H](C(N[C@H](C(CO)=O)C[C@H]1C(NCCC1)=O)=O)CC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mCMX110 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mCMX1102883773-06-4mCMX 110mCMX-110SARS-CoVVirus ProteaseSARS coronavirusCYP isoformsOmicron variant SARS-CoV-2HCT-8 cellsmini-Ames assaySARS-CoV-2 MproAlpha variant SARS-CoV-2HeLa-ACE2 cellsSARS-CoV-2 infectionHCoV-OC43SARS-CoV-2 main proteaseInhibitorinhibitorinhibit

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