2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Mesyl Salvinorin B

Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice.

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Mesyl Salvinorin B

Mesyl Salvinorin B Chemische Struktur

CAS. Nr. : 862073-79-8

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Mesyl Salvinorin B Related Antibodies

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Beschreibung

Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
30 1
Compound: 15
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
[PMID: 16033256]
CHO EC50
30 1
Compound: 15
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
[PMID: 16033256]
In Vivo

Mesyl Salvinorin B (0.3, 1, 3 mg/kg; i.p.; once) prevents the ADE at 3 mg/kg in both male and female mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks, Male and female adult C57BL/6J mice[1]
Dosage: 0.3, 1, 3 mg/kg
Administration: I.p.; once
Result: Showed less intake than the vehicle-treated ones in the ADE (Alcohol deprivation effect) session at 3 mg/kg.
Molekulargewicht

468.52

Formel

C22H28O9S
CAS. Nr.
SMILES

O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Mesyl Salvinorin B Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mesyl Salvinorin B862073-79-8Opioid ReceptorInhibitorinhibitorinhibit

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