862073-79-8
Chemical Structure
Mesyl Salvinorin B
- CAS No.: 862073-79-8
- Formula:C22H28O9S
- Molecular Weight:468.52
IUPAC Name: methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-9-((methylsulfonyl)oxy)-4,10-dioxododecahydro-2H-benzo[f]isochromene-7-carboxylate
InChIKey: JPQCLBRBPPZECE-VOVNARLJSA-N
SMILES: O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
Biological Activity: Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice[1][2].
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Mesyl Salvinorin B | Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice. | |||||||||||||||||||||
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- [1]. Zhou Y, et al. Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett. 2018 Apr 23;673:19-23. [Content Brief]
- [2]. Zhou Y, et al. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Res. 2017 May 1;1662:75-86. [Content Brief]
Keywords
