2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Mesyl Salvinorin B

Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice.

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Mesyl Salvinorin B Chemical Structure

Mesyl Salvinorin B Chemical Structure

CAS No. : 862073-79-8

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Description

Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice[1][2].

In Vivo

Mesyl Salvinorin B (0.3, 1, 3 mg/kg; i.p.; once) prevents the ADE at 3 mg/kg in both male and female mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks, Male and female adult C57BL/6J mice[1]
Dosage: 0.3, 1, 3 mg/kg
Administration: I.p.; once
Result: Showed less intake than the vehicle-treated ones in the ADE (Alcohol deprivation effect) session at 3 mg/kg.
Molecular Weight

468.52

Formula

C22H28O9S
CAS No.
SMILES

O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Mesyl Salvinorin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mesyl Salvinorin B862073-79-8Opioid ReceptorInhibitorinhibitorinhibit

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