Mesyl Salvinorin B
Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice.
For research use only. We do not sell to patients.
- CAS No.: 862073-79-8
- Formula: C22H28O9S
- Molecular Weight:468.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
30 nM
Compound: 15
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Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
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[PMID: 16033256] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8 weeks, Male and female adult C57BL/6J mice[1]
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Dosage:0.3, 1, 3 mg/kg
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Administration:I.p.; once
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Result:Showed less intake than the vehicle-treated ones in the ADE (Alcohol deprivation effect) session at 3 mg/kg.
Chemical Information
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CAS No. 862073-79-8
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Molecular Weight 468.52
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Formula C22H28O9S
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SMILES
O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhou Y, et al. Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett. 2018 Apr 23;673:19-23. [Content Brief]
[2]. Zhou Y, et al. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Res. 2017 May 1;1662:75-86. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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