2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. Metamizole

Metamizole  (Synonyms: Dipyrone free base; Methamizole)

Cat. No.: HY-148147
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Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.

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Metamizole

Metamizole Estructura química

No. CAS : 50567-35-6

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Descripciòn

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1].

In Vivo

Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity[1].
Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.
Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Induced reduction in hepatic glutathione (GSH) content in mice.
Peso molecular

311.36

Fòrmula

C13H17N3O4S
No. CAS
SMILES

O=C1C(N(CS(=O)(O)=O)C)=C(C)N(C)N1C2=CC=CC=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Metamizole Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metamizole50567-35-6Dipyrone MethamizoleThyroid Hormone ReceptorTHRanti-thyroidthyroid hormonethyroid glandhepatotoxicityInhibitorinhibitorinhibit

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Metamizole
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