2. Anti-infection
  3. Fungal
  4. Metconazole

Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat.

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Metconazole

Metconazole 構造式

CAS 番号 : 125116-23-6

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100 mg $25 在庫あり
250 mg $45 在庫あり
500 mg $60 在庫あり
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Metconazole 関連抗体

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製品説明

Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat[1].

体外実験

Metconazole (0.001-0.1 μg/mL; 3 days) potently inhibits mycelial growth of 39 Fusarium pseudograminearum strains, with a mean EC50 value of 0.019 μg/mL[1].
Metconazole (0.05-0.2 μg/mL; 6-12 h) inhibits conidial formation, germination, and germ tube elongation of 39 Fusarium pseudograminearum strains[1].
Metconazole (0.02-0.2 μg/mL; 6 h) induces significant transcriptional changes in Fusarium pseudograminearum strain PY20-16, including upregulation of ergosterol biosynthesis genes and nine ABC transporter genes[1].
Metconazole (0.002-0.2 μg/mL; 7 days) at 0.02 and 0.2 μg/mL inhibits DON, 15-ADON, and ZEN production in Fusarium pseudograminearum strains CF1494 and PY20-16, while 0.002 μg/mL stimulates DON and 15-ADON production but still inhibits ZEN production[1].
Metconazole (0.05-0.2 μg/mL; 12 h) significantly reduces ergosterol production in Fusarium pseudograminearum strain PY20-16 in a dose-dependent manner[1].
Metconazole (0.05-0.2 μg/mL) significantly reduces catalase and peroxidase activities in Fusarium pseudograminearum mycelia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metconazole 関連抗体
体内実験

Metconazole (0.06-0.14 μl AI/g seeds; seed treatment) provides 32.79-77.24% control efficacy against Fusarium crown rot in wheat under greenhouse conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seeds (Jimai 19)[1]
Dosage: 0.06 μl AI/g seeds; 0.1 μl AI/g seeds; 0.14 μl AI/g seeds
Administration: seed treatment
Result: Achieved 32.79% control efficacy against Fusarium crown rot at 0.06 μl AI/g seeds.
Achieved 59.16% control efficacy against Fusarium crown rot at 0.1 μl AI/g seeds.
Achieved 77.24% control efficacy against Fusarium crown rot at 0.14 μl AI/g seeds.
Significantly reduced disease occurrence.
分子量

319.83

分子式

C17H22ClN3O
CAS 番号
Unlabeled CAS
Appearance

Solid

SMILES

ClC1=CC=C(C=C1)CC2CCC(C)(C)C2(O)CN3N=CN=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
純度とドキュメンテーション
参考文献
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Metconazole Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metconazole125116-23-6Fungalergosterol biosynthesistoxin biosynthesis genes14α-demethylaseFusarium crown rotwheatABC transporter genesmycelial growthconidial germ tube elongationantioxidant enzyme activitiesFusarium pseudograminearumInhibitorinhibitorinhibit

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