2. Anti-infection
  3. Influenza Virus
  4. Methyl brevifolincarboxylate

Methyl brevifolincarboxylate  (Synonyms: Brevifolincarboxylic acid methyl ester)

Art. -Nr.: HY-N7647
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Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation.

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Methyl brevifolincarboxylate

Methyl brevifolincarboxylate Chemische Struktur

CAS. Nr. : 154702-76-8

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Methyl brevifolincarboxylate Related Antibodies

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Beschreibung

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation[1][2][4][5][6].

Cellular Effect
Cell Line Type Value Description References
Erythrocyte IC50
1.04 mM
Compound: 13
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
[PMID: 29631958]
Erythrocyte IC50
1.26 mM
Compound: 13
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
[PMID: 29631958]
In Vitro

Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM[2].
Methyl brevifolincarboxylate (10 and 30 μM) inhibits NO and TNF-α production in LPS stimulated macrophages[2].
Methyl brevifolincarboxylate (1 and 10 μM) inhibits Norepinephrine (HY-13715)-induced contractions of rat aorta[3].
Methyl brevifolincarboxylate (5 μM) inhibits platelet aggregation by 73.5%[4].
Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM[5].
Methyl brevifolincarboxylate (10-80 μM, 48 h) reduces TG Levels in OA-Treated SK-HEP-1 Cells and Primary Murine Hepatocytes[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methyl brevifolincarboxylate Related Antibodies

Cell Viability Assay[6]

Cell Line: SK-HEP-1 cells
Concentration: 10, 20, 40, 80 μM
Incubation Time: 48 h
Result: Reduced the protein levels of FASN, SREBP-1c and ACC1.
Increased the expression of PPAR-α.
Molekulargewicht

306.22

Formel

C14H10O8
CAS. Nr.
SMILES

O=C(C1CC(C2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O)=O)OC
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
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Methyl brevifolincarboxylate Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl brevifolincarboxylate154702-76-8Brevifolincarboxylic acid methyl esterInfluenza VirusMacrophageLPSDPPHNOplateletrat aortaNorepinephrineInhibitorinhibitorinhibit

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