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milbemycin-

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By Targets:	Antibiotic (10) Bacterial (2) Environmental Pollutants (1) Insecticide (4) P-glycoprotein (2) Parasite (9) Reference Standards (3)
By Research Areas:	Cancer (2) Infection (12)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0778

Milbemycin oxime 1 Publications Verification	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-130423

Milbemycin A3	Insecticide	Infection
Milbemycin A3 is a 16-membered macrocyclic lactone compound found in the soil bacterium Saccharopolyspora hygroscopicus subsp. aureolacrimosus. Milbemycin A3 enhances the opening of glutamate- and GABA-gated chloride channels and exhibits insecticidal activity. Milbemycin A3 can be used in insect resistance-related research .

HY-126906

Milbemycin A4	Environmental Pollutants Antibiotic P-glycoprotein	Cancer
Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity sup>[2].

HY-126906R

Milbemycin A4 (Standard)	Reference Standards Antibiotic P-glycoprotein	Cancer
Milbemycin A4 (Standard) is the analytical standard of Milbemycin A4. This product is intended for research and analytical applications. Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity sup> .

HY-B0778R

Milbemycin oxime (Standard)	Reference Standards Antibiotic Parasite	Infection
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-130423R

Milbemycin A3 (Standard)	Insecticide Reference Standards	Infection
Milbemycin A3 (Standard) is the analytical standard of Milbemycin A3 (HY-130423). This product is intended for research and analytical applications. Milbemycin A3 is a 16-membered macrocyclic lactone compound found in the soil bacterium Saccharopolyspora hygroscopicus subsp. aureolacrimosus. Milbemycin A3 enhances the opening of glutamate- and GABA-gated chloride channels and exhibits insecticidal activity. Milbemycin A3 can be used in insect resistance-related research .

HY-N15090

Milbemycin α10	Antibiotic Bacterial Insecticide	Infection
Milbemycin α10 is a macrolide antibiotic. Milbemycin α10 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

HY-N14860

Milbemycin β3	Antibiotic Bacterial	Infection
Milbemycin β3 is a macrolide antibiotic. Milbemycin β3 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

HY-N15096

Milbemycin α14	Antibiotic Parasite	Infection
Milbemycin α14 is an antibiotic and has the effect of killing nematodes and mites .

HY-N15093

Milbemycin α12	Antibiotic Parasite	Infection
Milbemycin α12 is an antibiotic and has the effect of killing nematodes and mites .

HY-N15098

Milbemycin α15	Parasite	Infection
Milbemycin α15 possess a potent antiparasitic activity, including acaricidal, insecticidal and nematocidal activities .

HY-118357

Milbemycin A3 Oxime	Parasite Insecticide
Milbemycin A3 Oxime is a macrocyclic lactone antiparasitic agent that exhibits potent inhibitory activity against Dirofilaria immitis .

HY-N15092

Milbemycin α11 Meilingmycin A	Antibiotic Parasite	Infection
Milbemycin α11 (Meilingmycin A) is an antibiotic and has the effect of killing nematodes and mites .

HY-N15094

Milbemycin α13 Meilingmycin B	Antibiotic Parasite	Infection
Milbemycin α13 (Meilingmycin B) is an antibiotic and has the effect of killing nematodes and mites .

HY-138074

Milbemycin A4 oxime 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime	Parasite	Infection
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC₈₀=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.

Milbemycin oxime 1 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

Milbemycin oxime (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Antibiotic Parasite
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

Milbemycin α10	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial Insecticide
Milbemycin α10 is a macrolide antibiotic. Milbemycin α10 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

Milbemycin β3	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Milbemycin β3 is a macrolide antibiotic. Milbemycin β3 has insecticidal effects on agricultural harmful insects, pans, larvae, etc .

Milbemycin α14	Microorganisms Antibiotics Source Classification	Antibiotic Parasite
Milbemycin α14 is an antibiotic and has the effect of killing nematodes and mites .

Milbemycin α12	Natural Products Microorganisms Antibiotics Source Classification	Antibiotic Parasite
Milbemycin α12 is an antibiotic and has the effect of killing nematodes and mites .

Milbemycin α15	Microorganisms Antibiotics Source Classification	Parasite
Milbemycin α15 possess a potent antiparasitic activity, including acaricidal, insecticidal and nematocidal activities .

Milbemycin α11 Meilingmycin A	Natural Products Microorganisms Source Classification	Antibiotic Parasite
Milbemycin α11 (Meilingmycin A) is an antibiotic and has the effect of killing nematodes and mites .

Milbemycin α13 Meilingmycin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Parasite
Milbemycin α13 (Meilingmycin B) is an antibiotic and has the effect of killing nematodes and mites .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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milbemycin-

Inhibitors & Agonists

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