2. GPCR/G Protein
  3. Neuropeptide B/W Receptor
  4. Neuropeptide W-23 (human)

Neuropeptide W-23 (human)  (Synonyms: NPW-23)

Cat. No.: HY-P1035 Pureté: 98.75%
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Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).

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Synthèse de peptides personnalisée

Neuropeptide W-23 (human)

Neuropeptide W-23 (human) Chemical Structure

CAS No. : 383415-79-0

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Other Forms of Neuropeptide W-23 (human):

Neuropeptide W-23 (human) Related Antibodies

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Description

Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)[1].

IC50 & Target

NPBW1, NPBW2[1]
In Vitro

Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide W-23 (human) Related Antibodies
In Vivo

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Harlan Sprague-Dawley rats, 250–300 g[2]
Dosage: 0.3, 1.0 and 3.0 nM
Administration: Intracerebroventricular injection, 2 μL
Result: Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model: Male Wistar rats weighing 250–300 g[3]
Dosage: 2, 4, 6 and 8 nM
Administration: Intra-cerebroventricular injection, 10 μL
Result: Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
Masse moléculaire

2584.01

Formule

C119H183N35O28S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu
Sequence Shortening

WYKHVASPRYHTVGRAAGLLMGL
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : ≥ 50 mg/mL (19.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3870 mL 1.9350 mL 3.8700 mL
5 mM 0.0774 mL 0.3870 mL 0.7740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3870 mL 1.9350 mL 3.8700 mL 9.6749 mL
5 mM 0.0774 mL 0.3870 mL 0.7740 mL 1.9350 mL
10 mM 0.0387 mL 0.1935 mL 0.3870 mL 0.9675 mL
15 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6450 mL
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Neuropeptide W-23 (human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide W-23 (human)383415-79-0NPW-23NPW23NPW 23Neuropeptide B/W ReceptorNPBW1NPBW2GPR7GPR8Neuropeptide Whypetensionanorexigenic effectInhibitorinhibitorinhibit

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