2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. NSC-57969

NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines.

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NSC-57969

NSC-57969 화학구조

CAS No. : 6632-09-3

사이즈 가격 재고 수량
1 mg 견적 받기 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
5 mg 견적 받기 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks
10 mg   견적 받기  
50 mg   견적 받기  
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NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines[1].

Cellular Effect
Cell Line Type Value Description References
BT-483 GI50
26.9 μM
Compound: 7
Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
[PMID: 19748786]
HeLa GI50
0.35 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2
[PMID: 19748786]
HeLa GI50
0.58 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2
[PMID: 19748786]
HeLa GI50
12.9 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2
[PMID: 19748786]
HeLa GI50
14.5 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
[PMID: 19748786]
HeLa GI50
3 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2
[PMID: 19748786]
HeLa GI50
8.5 μM
Compound: 7
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2
Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2
[PMID: 19748786]
MES-SA IC50
4.18 μM
Compound: 3
Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay
Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay
[PMID: 35613553]
MES-SA IC50
5.21 μM
Compound: 3
Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay
Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay
[PMID: 35613553]
MES-SA/Dx5 IC50
0.85 μM
Compound: 3
Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay
Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay
[PMID: 35613553]
MES-SA/Dx5 IC50
2.69 μM
Compound: 3
Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay
Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay
[PMID: 35613553]
분자량

242.32

화학식

C15H18N2O
CAS No.
SMILES

OC1=C2N=CC=CC2=CC=C1CN3CCCCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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NSC-57969 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC-579696632-09-3NSC57969NSC 57969P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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상품명:
NSC-57969
Cat. No.:
HY-116976
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