Octaethylene glycol monododecyl ether (Synonyms: C12E8)

Name: Octaethylene glycol monododecyl ether
Brand: MedChemExpress
SKU: HY-138941
Rating: 4.5 (1 reviews)

Cat. No.: HY-138941 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Octaethylene glycol monododecyl ether (C12E8) is an non-ionic detergent that can be used for membrane protein extraction. Octaethylene glycol monododecyl ether can solubilize the viral membrane of intact influenza virus.

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Octaethylene glycol monododecyl ether 화학구조

CAS No. : 3055-98-9

사이즈	재고	수량
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Liquid
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Octaethylene glycol monododecyl ether:

Octaethylene glycol monododecyl ether (Standard) 견적 받기

1 Publications Citing Use of MCE Octaethylene glycol monododecyl ether

•National Autonomous University of Mexico. 2025.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
MOLT-4	IC₅₀	29 μM Compound: HL-8	Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay Growth inhibition of HIV1 3B infected human MOLT4 cells after 5 days by MTT assay	[PMID: 18672367]
MOLT-4	IC₅₀	59 μM Compound: HL-8	Growth inhibition of human MOLT4 cells after 5 days by MTT assay Growth inhibition of human MOLT4 cells after 5 days by MTT assay	[PMID: 18672367]

In Vitro

Octaethylene glycol monododecyl ether (C12E8) has been shown to solubilize the viral membrane of intact influenza virus. The mechanism of solubilization of the viral membrane is based on the accumulation of C12E8 molecules outside the membrane until the formation of micelles leading to the extraction of membrane constituents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

538.75

화학식

C₂₈H₅₈O₉

CAS No.

3055-98-9

Appearance

Liquid (Density: 0.984～0.992 g/cm³)

Color

Colorless to light yellow

SMILES

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (185.61 mM)

DMSO : 100 mg/mL (185.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8561 mL	9.2807 mL	18.5615 mL
5 mM	0.3712 mL	1.8561 mL	3.7123 mL
10 mM	0.1856 mL	0.9281 mL	1.8561 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (269 KB) SDS (615 KB)

COA (242 KB) HNMR (275 KB) MS (82 KB)

Handling Instructions (2659 KB)

References

[1]. Véronique Nardello-Rataj, et al. Aqueous solutions of didecyldimethylammonium chloride and octaethylene glycol monododecyl ether: Toward synergistic formulations against enveloped viruses. Int J Pharm. 2016 Sep 10;511(1):550-559. [Content Brief]

[2]. C Carnero Ruiz, et al. Characterization of mixed non-ionic surfactants n-octyl-β-D-thioglucoside and octaethylene-glycol monododecyl ether: micellization and microstructure. J Colloid Interface Sci. 2011 Sep 1;361(1):178-85. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8561 mL	9.2807 mL	18.5615 mL	46.4037 mL
	5 mM	0.3712 mL	1.8561 mL	3.7123 mL	9.2807 mL
	10 mM	0.1856 mL	0.9281 mL	1.8561 mL	4.6404 mL
	15 mM	0.1237 mL	0.6187 mL	1.2374 mL	3.0936 mL
	20 mM	0.0928 mL	0.4640 mL	0.9281 mL	2.3202 mL
	25 mM	0.0742 mL	0.3712 mL	0.7425 mL	1.8561 mL
	30 mM	0.0619 mL	0.3094 mL	0.6187 mL	1.5468 mL
	40 mM	0.0464 mL	0.2320 mL	0.4640 mL	1.1601 mL
	50 mM	0.0371 mL	0.1856 mL	0.3712 mL	0.9281 mL
	60 mM	0.0309 mL	0.1547 mL	0.3094 mL	0.7734 mL
	80 mM	0.0232 mL	0.1160 mL	0.2320 mL	0.5800 mL
	100 mM	0.0186 mL	0.0928 mL	0.1856 mL	0.4640 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Octaethylene glycol monododecyl ether Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octaethylene glycol monododecyl ether3055-98-9C12E8Influenza Virusnon-ionicdetergentmembraneproteininfluenzavirusInhibitorinhibitorinhibit

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Octaethylene glycol monododecyl ether (Synonyms: C12E8)

고객리뷰

Other Forms of Octaethylene glycol monododecyl ether:

Octaethylene glycol monododecyl ether Related Antibodies

1 Publications Citing Use of MCE Octaethylene glycol monododecyl ether

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Octaethylene glycol monododecyl ether Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Octaethylene glycol monododecyl ether Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report