2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Olezarsen sodium

Olezarsen sodium  (Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium)

Cat. No.: HY-153491A Purity: 96.53%
COA
SDS
Handling Instructions Technical Support

Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)

Olezarsen sodium 화학구조

CAS No. : 2298451-31-5

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Olezarsen sodium:

Olezarsen sodium Related Antibodies

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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제품 설명

Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease[1][2][3].

IC50 & Target

apoC3

 

In Vitro

Olezarsen not only reduces triglycerides and APOC3, but also decreases ApoB and non-HDL-C. Moreover, it improves dyslipidemia risk through multiple mechanisms, including reducing triglyceride-rich lipoprotein (TRL) remnants, remodeling low-density lipoprotein (LDL) particles, and increasing specific high-density lipoprotein (HDL) subclasses[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olezarsen sodium Related Antibodies
분자량

8684.86 (free acid)

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Olezarsen (sodium)]
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서

Purity: 96.53%

SDS (252 KB)

COA (247 KB) LCMS (328 KB)

Handling Instructions (2242 KB)
References
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Olezarsen sodium Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olezarsen2298451-31-5ISIS 678354IONIS-APOCIII-LRxAKCEA-APOCIII-LRxISIS678354ISIS-678354Apolipoproteintriglyceride-rich lipoprotein particleLDL particlesAPOC3 mRNAplasma triglycerideapolipoprotein Bnon-HDL cholesterolfamilial chylomicronemia syndromeapolipoprotein C-IIIribonuclease H1HDL-PInhibitorinhibitorinhibit

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상품명:
Olezarsen sodium
Cat. No.:
HY-153491A
수량:
MCE Japan Authorized Agent:

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