2. Immunology/Inflammation Cytoskeleton Cell Cycle/DNA Damage
  3. FAP Microtubule/Tubulin
  4. OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE  (Synonyms: OncoFAP glidotin)

Cat. No.: HY-175350 Pureza: 99.71%
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OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49  nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research.

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OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE Estructura química

No. CAS : 2688118-55-8

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1 mg En stock
5 mg En stock
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100 mg   Obtener un presupuesto  

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OncoFAP-GlyPro-MMAE Related Antibodies

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Descripciòn

OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49  nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research[1].

Peso molecular

2135.38

Fòrmula

C102H141F2N19O27S
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC(N1[C@H](C#N)CC(F)(F)C1)=O)C2=CC=NC3=C(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@](CCC7)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C8=CC=CC=C8)O)=O)=O)=O)=O)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)C=CC=C32
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (46.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4683 mL 2.3415 mL 4.6830 mL
5 mM 0.0937 mL 0.4683 mL 0.9366 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4683 mL 2.3415 mL 4.6830 mL 11.7075 mL
5 mM 0.0937 mL 0.4683 mL 0.9366 mL 2.3415 mL
10 mM 0.0468 mL 0.2342 mL 0.4683 mL 1.1708 mL
15 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7805 mL
20 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.5854 mL
25 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
30 mM 0.0156 mL 0.0781 mL 0.1561 mL 0.3903 mL
40 mM 0.0117 mL 0.0585 mL 0.1171 mL 0.2927 mL
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OncoFAP-GlyPro-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OncoFAP-GlyPro-MMAE2688118-55-8OncoFAP glidotinFAPMicrotubule/TubulinFibroblast activation proteinSmall molecule-drug conjugateSMDCTubulinMMAECancersInhibitorinhibitorinhibit

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Nombre del producto:
OncoFAP-GlyPro-MMAE
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HY-175350
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