PD-1/PD-L1-IN-24
PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs.
For research use only. We do not sell to patients.
- CAS No.: 2667680-33-1
- Formula: C34H30ClN5O6
- Molecular Weight:640.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.57 nM (PD-1/PD-L1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
12.42 μM
Compound: 39
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Cytotoxicity against human PBMC cells assessed as reduction in cell growth incubated for 72 hrs by CCK8 assay
Cytotoxicity against human PBMC cells assessed as reduction in cell growth incubated for 72 hrs by CCK8 assay
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[PMID: 34839997] |
PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM[1].
PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC50 is 12.42 μM[1].
PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PBMC[1]
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Concentration:0.003, 0.0091, 0.027, 0.082, 0.247, 0.741, 2.222, 6.67 and 20 μM
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Incubation Time:72 hours
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Result:No significant toxicity was observed at concentrations ranging from 0.003 to 2.22 μM, and the IC50 was 12.42 μM.
Chemical Information
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CAS No. 2667680-33-1
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Molecular Weight 640.08
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Formula C34H30ClN5O6
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SMILES
N#CC1=CN=CC(COC2=CC(OC3=NC=NC4=C3C=CC=C4C5=CC6=C(OCCO6)C=C5)=C(C=C2CNC(CO)(CO)C)Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1-IN-24 Related Classifications
HY-144649 Related Classifications
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