2667680-33-1
Chemical Structure
PD-1/PD-L1-IN-24
- CAS No.: 2667680-33-1
- Formula:C34H30ClN5O6
- Molecular Weight:640.08
IUPAC Name: 5-((4-chloro-5-((8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)quinazolin-4-yl)oxy)-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)nicotinonitrile
InChIKey: PHMZZTDGCZKZPG-UHFFFAOYSA-N
SMILES: N#CC1=CN=CC(COC2=CC(OC3=NC=NC4=C3C=CC=C4C5=CC6=C(OCCO6)C=C5)=C(C=C2CNC(CO)(CO)C)Cl)=C1
Biological Activity: PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs[1].
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PD-1/PD-L1-IN-24 | PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs. | |||||||||||||||||||||
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Keywords
