2. Anti-infection
  3. Bacterial
  4. Peceleganan

Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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Peceleganan

Peceleganan 構造式

CAS 番号 : 850761-47-6

容量 価格（税別） 在庫状況 数量
1 mg $110 在庫あり
5 mg $290 在庫あり
10 mg $470 在庫あり
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100 mg   お問い合わせ  

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Peceleganan 関連抗体

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製品説明

Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection[1].

体外実験

Peceleganan (24 h) shows antibacterial activity with MICs of 2, 2, 4, 4, 4 and 8 μM against E. coli ATCC 25922, S. pneumonia ATCC 49619, K. pneumonia ATCC 700603, S. aureus ATCC 25923, S. epidermidis ATCC 12228 and P. aeruginosa ATCC 27853, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peceleganan 関連抗体
体内実験

Peceleganan (0.4 and 0.75 mg/mL for 100 μL; transdermal; twice daily for 3 days) inhibits Staphylococcus aureus in the mouse infection model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (20-25 g), S. aureus ATCC 25923 wound infection model[2]
Dosage: 0.4 and 0.75 mg/mL for 100 μL
Administration: Transdermal administration, twice daily for 3 days
Result: Significantly reduced the amount of bacteria.
臨床実験
分子量

2933.50

分子式

C₁₃₈H₂₂₆N₃₆O₃₄
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  内容 Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
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参考文献
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Peceleganan Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peceleganan850761-47-6PL-5PL5PL 5Bacterialantimicrobialcecropin Amelittin Bwound infectionInhibitorinhibitorinhibit

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製品名:
Peceleganan
製品番号:
HY-P3383
数量:
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