Phenylacetic acid mustard

Art. -Nr.: HY-136327: Data Sheet Handling Instructions
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Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity.

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Phenylacetic acid mustard Chemische Struktur

CAS. Nr. : 10477-72-2

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

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Beschreibung

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity^[1].

IC₅₀ & Target

IC50: metabolite of Chlorambucil^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
LoVo	IC₅₀	19 μM Compound: 5a	Inhibitory concentration was evaluated against colorectal tumar cell line LoVo Inhibitory concentration was evaluated against colorectal tumar cell line LoVo	[PMID: 8676345]

In Vivo

Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED₁₅ value of 8.0 mg/kg^[2].
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Inbred male C3H/He mice^[1]
Dosage:	0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:	Intraperitoneal injection; 15 days
Result:	Exhibited anti-tumor activities in vivo.

Molekulargewicht

276.16

Formel

C₁₂H₁₅Cl₂NO₂

CAS. Nr.

10477-72-2

SMILES

O=C(O)CC1=CC=C(N(CCCl)CCCl)C=C1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Lösungsmittel & Löslichkeit

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

Phenylacetic acid mustard (PAAM) is dissolved in acidified ethanol (4.8 ml cone HC1 and 95% v/v ethyl alcohol in a volume of 100 ml) and diluted 1:9 with propylene glycol/K2HPO 4 buffer (20 g K2HPO4 plus 450 ml propylene glycol), final pH 7.4^[2].

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Toni Pettersson-Fernholm, et al. Reactions of 4-bis(2-chloroethyl)aminophenylacetic acid (phenylacetic acid mustard) in physiological solutions.

[2]. F Y Lee, et al. Pharmacokinetic basis for the comparative antitumour activity and toxicity of chlorambucil, phenylacetic acid mustard and, -difluorochlorambucil (CB 7103) in mice. [Content Brief]