1. Apoptosis
    Protein Tyrosine Kinase/RTK
  2. Apoptosis
    FGFR
  3. Picrasidine Q

Picrasidine Q 

Cat. No.: HY-N9507
Handling Instructions

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity.

For research use only. We do not sell to patients.

Picrasidine Q Chemical Structure

Picrasidine Q Chemical Structure

CAS No. : 101219-61-8

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Description

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].

IC50 & Target[1]

FGFR2

 

In Vitro

Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 3 hours
Result: Suppressed downstream signaling of FGFR2 in ESCC cells.

Apoptosis Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 48 and 72 hours
Result: Induced cell cycle arrest and apoptosis.

Cell Cytotoxicity Assay[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 24~72 hours
Result: Suppressed the growth of ESCC cells.

Cell Cycle Analysis[1]

Cell Line: JB6Cl41 cells
Concentration: 0~60 μM
Incubation Time: 30 minutes
Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.
Molecular Weight

266.25

Formula

C₁₅H₁₀N₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Picrasidine Q
Cat. No.:
HY-N9507
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