Pim-1/2 kinase inhibitor 1

Name: Pim-1/2 kinase inhibitor 1
Brand: MedChemExpress
SKU: HY-W412264
Rating: 4.5 (0 reviews)

製品番号: HY-W412264 純度: 99.78%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.

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Pim-1/2 kinase inhibitor 1 構造式

CAS 番号 : 6320-51-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 104	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 104	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$95	在庫あり	Estimated Time of Arrival: December 31
10 mg	$155	在庫あり	Estimated Time of Arrival: December 31
25 mg	$310	在庫あり	Estimated Time of Arrival: December 31
50 mg	$495	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Pim アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PIM1 PIM2 PIM3

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	172 3 Compound: 19a	Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34826680]
HepG2	EC₅₀	200 3 Compound: 19a	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34826680]
PC-12	IC₅₀	23 3 Compound: 11b	Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay	[PMID: 15109648]
PC-3	IC₅₀	11 3 Compound: 10a	Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay	[PMID: 19072652]

体外実験

Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	PC3 cells
Concentration:	varying concentrations
Incubation Time:	48 h
Result:	Inhibited PC3 cells with an IC of 11 µM.

分子量

235.26

分子式

C₁₁H₉NO₃S

CAS 番号

6320-51-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (1062.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2506 mL	21.2531 mL	42.5062 mL
5 mM	0.8501 mL	4.2506 mL	8.5012 mL
10 mM	0.4251 mL	2.1253 mL	4.2506 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.78%

Select Batch:

データシート (272 KB) SDS (393 KB)

COA (248 KB) HNMR (258 KB) RP-HPLC (246 KB) MS (73 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2506 mL	21.2531 mL	42.5062 mL	106.2654 mL
	5 mM	0.8501 mL	4.2506 mL	8.5012 mL	21.2531 mL
	10 mM	0.4251 mL	2.1253 mL	4.2506 mL	10.6265 mL
	15 mM	0.2834 mL	1.4169 mL	2.8337 mL	7.0844 mL
	20 mM	0.2125 mL	1.0627 mL	2.1253 mL	5.3133 mL
	25 mM	0.1700 mL	0.8501 mL	1.7002 mL	4.2506 mL
	30 mM	0.1417 mL	0.7084 mL	1.4169 mL	3.5422 mL
	40 mM	0.1063 mL	0.5313 mL	1.0627 mL	2.6566 mL
	50 mM	0.0850 mL	0.4251 mL	0.8501 mL	2.1253 mL
	60 mM	0.0708 mL	0.3542 mL	0.7084 mL	1.7711 mL
	80 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.3283 mL
	100 mM	0.0425 mL	0.2125 mL	0.4251 mL	1.0627 mL