2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Plozasiran

Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Am-Cm-Gm-Gm-Gm-Am-Cm-Am- (2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)A-Um-Um-Cm-Um-CmAm-Gm-Um-Im-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4- [(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2- (acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]- 1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Am-sp-(2'- deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Am-Gm-Am-Am-Um-(2'-deoxy-2'- fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)CCm-(2'-deoxy-2'-fluoro)G-sp-Um) (1:1)

Plozasiran Chemische Struktur

CAS. Nr. : 2379776-40-4

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Other Forms of Plozasiran:

Plozasiran Related Antibodies

Top Publications Citing Use of Products

Alle Apolipoprotein Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Beschreibung

Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia.

IC50 & Target

apoC3

 

In Vitro

Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The short dsRNA unwinds and the sense strand is degraded. Antisense strand forms RNA induced silencing complex (RISC) with various protein components. The antisense strand retained in RISC is specifically complementary to the target gene mRNA. Meanwhile, RISC has nuclease activity, which can cut and degrade the target gene mRNA, and inhibit the expression of target gene. Incomplete complementarity results in mRNA translation inhibition.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Plozasiran Related Antibodies
Molekulargewicht

15618.77

CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

[Plozasiran]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Purity: 99.00%

SDS (252 KB)

COA (250 KB) RP-HPLC (206 KB) LCMS (536 KB)

Handling Instructions (2242 KB)
Verweise
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Plozasiran Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plozasiran2379776-40-4ARO-APOC3ApolipoproteinInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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