Protease-Activated Receptor-1, PAR-1 Agonist

Name: Protease-Activated Receptor-1, PAR-1 Agonist
Brand: MedChemExpress
SKU: HY-P2518
Rating: 4.5 (0 reviews)

製品番号: HY-P2518 純度: 99.70%: Data Sheet SDS COA 取扱説明書
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Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.

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Protease-Activated Receptor-1, PAR-1 Agonist 構造式

CAS 番号 : 141136-85-8

容量	価格（税別）	在庫状況	数量
1 mg	$50	在庫あり	Estimated Time of Arrival: December 31
5 mg	$125	在庫あり	Estimated Time of Arrival: December 31
10 mg	$190	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Protease-Activated Receptor-1, PAR-1 Agonist:

Protease-Activated Receptor-1, PAR-1 Agonist TFA 在庫あり

Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PAR1 PAR2 PAR4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

PAR1

体外実験

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor G? 6976^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

762.90

分子式

C₃₅H₅₈N₁₀O₉

CAS 番号

141136-85-8

Appearance

Solid

Color

White to off-white

Sequence

Thr-Phe-Leu-Leu-Arg-Asn

Sequence Shortening

TFLLRN

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)

溶剤 & 溶解度

体外:

H₂O : ≥ 12.5 mg/mL (16.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3108 mL	6.5539 mL	13.1079 mL
5 mM	0.2622 mL	1.3108 mL	2.6216 mL
10 mM	0.1311 mL	0.6554 mL	1.3108 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.70%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (250 KB) LCMS (91 KB) Elemental Analysis Report (109 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Stefanie Gödecke, et al. Thrombin-induced ATP release from human umbilical vein endothelial cells. Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C915-23. [Content Brief]

[2]. Heider I, et al. PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncol Res. 2004;14(10):475-482. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3108 mL	6.5539 mL	13.1079 mL	32.7697 mL
	5 mM	0.2622 mL	1.3108 mL	2.6216 mL	6.5539 mL
	10 mM	0.1311 mL	0.6554 mL	1.3108 mL	3.2770 mL
	15 mM	0.0874 mL	0.4369 mL	0.8739 mL	2.1846 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.