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  2. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
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  4. FGFR-4/CD334 FGFR
  5. FGFR-4
  6. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc)

FGFR-4 Protein, Rhesus Macaque (HEK293, Fc)

Cat. No.: HY-P76928
Handling Instructions

The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is 369 a.a., with molecular weight of ~65.6 KDa.

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Description

The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is 369 a.a., with molecular weight of ~65.6 KDa.

Background

FGFR-4 protein, as a cell surface receptor for tyrosine kinase and fibroblast growth factor, plays a key role in regulating multiple pathways, including cell proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. Structurally, the protein consists of an extracellular region with three immunoglobulin-like domains, a hydrophobic membrane span segment, and a cytoplasmic tyrosine kinase domain. Through the extracellular portion of its interaction with fibroblast growth factor, FGFR-4 initiates downstream signaling cascades that ultimately influence mitosis and differentiation. This gene showed widespread expression, with elevated levels observed in the lung (RPKM 16.7), kidney (RPKM 12.5), and 15 other tissues, underscoring its potential significance in different physiological Settings in different organs. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7[1][2][3].

Species

Rhesus Macaque

Source

HEK293

Tag

C-mFc

Accession

XP_001087243 (M1-D369)

Gene ID
Molecular Construction
N-term
FGFR-4 (M1-D369)
Accession # XP_001087243
mFc
C-term
Synonyms
Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF
Molecular Weight

Approximately 65.6 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FGFR-4 Protein, Rhesus Macaque (HEK293, Fc)
Cat. No.:
HY-P76928
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