FGFR-1 Protein, Rhesus Macaque (HEK293, Fc)

FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag.

FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 activates multiple signaling cascades, phosphorylating key proteins such as PLCG1, FRS2, GAB1, and SHB. This activation results in the production of signaling molecules via PLCG1. FRS2 phosphorylation triggers recruitment of GRB2, GAB1, PIK3R1, and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR1 also promotes phosphorylation of SHC1, STAT1, and PTPN11/SHP2. In the nucleus, it can enhance the activity of RPS6KA1 and CREB1 and participate in transcriptional regulation. Down-regulation of FGFR1 signaling occurs through IL17RD/SEF and FGFR1 ubiquitination, internalization, and degradation^[1][2][3]

Rhesus Macaque

HEK293

C-hFc

H9FRD4/NP_001253576.1 (R22-Y283)

700126  [NCBI]

Partial

RPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLY

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.