IL-13R alpha 1 Protein, Rat (HEK293, Fc)

Interleukin 13 receptor subunit alpha 1 is a subunit of the interleukin 13 receptor. Interleukin 13 receptor subunit alpha 1 has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL-13R alpha 1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-hFc labeled tag.

Interleukin 13 receptor subunit alpha 1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. Interleukin 13 receptor subunit alpha 1 has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. Interleukin 13 receptor subunit alpha 1 enables protein binding and is involved in cell surface receptor signaling pathway^{[1][2][3][4][5]}.

Measured by its binding ability in a functional ELISA. When recombinant rat IL-13R alpha 1 at 4 µg/mL (100 µL/well) can bind recombinant human IL-13. The ED₅₀ for this effect is 25.58 ng/mL.

• 
  Measured by its binding ability in a functional ELISA. When recombinant rat IL-13R alpha 1 at 4 µg/mL (100 µL/well) can bind recombinant human IL-13 .The ED₅₀ for this effect is 25.58 ng/mL.

Rat

HEK293

C-hFc

Q561K3 (T27-T342)

100360218  [NCBI]

Partial

TEVQPPVTNLSVSVENLCTIVWTWSPPEGASPNCSLRYFSHFDDQQDKKIAPETRRKKELPLNEKICLQVGSQCSTNESEKPSPLVKKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGKNTSPDTNYTLYYWYSSLGKSLQCENIHREGQHIGCSFKLTKVESNYEHHNIQIMVKDNAGKIRPSYKIVSFTSNVKPGPPHIKHLFLKNGALFVQWKNPQNFSSRCLSYEVEVNSTQTDSYNSNSLEVEEDKCQNSEFDRNMEGASCFISPGVLANTVYTVRVRVKTNKLCFDDNDLWSNWSEALSIGKEPNST

approximately 90 kDa

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.