IL-31R alpha Protein, Human (HEK293, Fc)

IL-31R alpha Proteinas associates with IgM heavy and light chains, aiding IgM assembly and secretion. It may act as a molecular chaperone or oxidoreductase, showing low oxidoreductase activity. Isoform 2 might regulate apoptosis. IL-31R alpha contributes to peripheral B-cell function diversification by modulating Ca(2+) stores, antibody secretion, and integrin activation. Additionally, it acts as a hormone-regulated adipokine/inflammatory cytokine, involved in chronic inflammation, impacting cellular expansion and insulin response in adipocytes, potentially contributing to insulin resistance onset. IL-31R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293, with C-hFc labeled tag. The total length of IL-31R alpha Protein, Human (HEK293, Fc) is 497 a.a., with molecular weight of ~130 kDa.

MZB1/PERP1 associates with immunoglobulin M (IgM) heavy and light chains, facilitating IgM assembly and secretion. It may function as a molecular chaperone or oxidoreductase, as it exhibits a low level of oxidoreductase activity. Additionally, isoform 2 may play a role in apoptosis regulation. MZB1/PERP1 contributes to the diversification of peripheral B-cell functions by modulating Ca(2+) stores, antibody secretion, and integrin activation. Furthermore, it acts as a hormone-regulated adipokine/pro-inflammatory cytokine implicated in chronic inflammation, affecting cellular expansion and attenuating insulin response in adipocytes, potentially playing a role in the onset of insulin resistance.

Data is not available.

Human

HEK293

C-hFc

Q8NI17/EAW54932.1 (A20-S516)

133396  [NCBI]

ALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMANTSAGGTNGTSINFKTLSFS

Approximately 130 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.