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IL31RA - interleukin 31 receptor A Gene

Also Known as CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 133396

About IL31RA

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,839,789-55,922,850 (from NCBI)

This gene has 13 transcripts (splice variants), 174 orthologues, 23 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

IL31RA Products (6)

mRNA	Protein	Name
NM_001242636.2	NP_001229565.1	interleukin-31 receptor subunit alpha isoform 2 precursor
NM_001242637.2	NP_001229566.1	interleukin-31 receptor subunit alpha isoform 3
NM_001242638.2	NP_001229567.1	interleukin-31 receptor subunit alpha isoform 4 precursor
NM_001242639.2	NP_001229568.1	interleukin-31 receptor subunit alpha isoform 5
NM_001297570.3	NP_001284499.1	interleukin-31 receptor subunit alpha isoform 6
NM_139017.7	NP_620586.3	interleukin-31 receptor subunit alpha isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IEP IEP: Inferred from expression pattern	11877449	GOA
involved in monocyte differentiation	IEP IEP: Inferred from expression pattern	11877449	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11877449	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IEP IEP: Inferred from expression pattern	11877449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL31RA Protein Structure

IL6Ra-bind

fn3

0
200
400
600
764 a.a.

Protein Preferred Names	Protein Names
interleukin-31 receptor subunit alpha	IL-31 receptor subunit alpha

Recombinant IL31RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75859	IL-31R alpha Protein, Human (HEK293, Fc)	EAW54932.1 (A33-S529)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75860	IL-31R alpha Protein, Human (HEK293, His)	Q8NI17-1/EAW54932.1 (A20-S516)	≥ 85%, as determined by reducing SDS-PAGE.

IL31RA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811003	IL-31RA Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Amyloidosis, Primary Localized Cutaneous, 2	PLCA2 Primary Localized Cutaneous Amyloidosis 2
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Lichen Amyloidosis	Amyloid Lichen Lichen Amyloidosus Amyloidosis, Primary Cutaneous
Macular Amyloidosis	Amyloidosis, Macular
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Amyloidosis, Primary Localized Cutaneous, 3	Amyloidosis Cutis Dyschromica PLCA3 Acd Primary Localized Cutaneous Amyloidosis 3 Amyloidosis Cutis Dyschromia
Neurodermatitis
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06755	IL31RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20557	Il31ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27066	Il31ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990713	Nolavetbart		96%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL31RA	MGD	MGI:2180511
Rattus norvegicus	IL31RA	RGD	RGD:1586478
Macaca mulatta	IL31RA	VGNC	VGNC:73624
Bos taurus	IL31RA	VGNC	VGNC:30154
Felis catus	IL31RA	VGNC	VGNC:62911
Canis familiaris	IL31RA	VGNC	VGNC:41981
Others	IL31RA	NCBI