IL-31RA Antibody
(Synonyms: CRL3, GPL, UNQ6368/PRO21073/PRO21384, IL31RA, Interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, Cytokine receptor-like 3, GLM-R, Gp130-like monocyte receptor, ZcytoR17, hGLM-R, Gp130-like receptor)IL-31RA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to IL-31RA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
IL-31RA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to IL-31RA.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 82; 64 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 82 kDa
Synthetic peptide corresponding to the center region of human IL-31RA.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-31RA functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31. Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity. Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (Probable). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity)[1][2][3][4].
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Subcellular Localization
Cell membrane; Presynaptic cell membrane; Cell projection, axon
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Expression
Tissue_Specificity: Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts. Detected in all of the myelomonocytic lineage. Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients.
Induction: Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG/IFN-gamma. Up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by triacylated lipoprotein (Pam3Cys). Up-regulated by TGFB1/TGF-beta. -
Isoforms & Post-Translational Modification
IL-31RA has 12 isoforms, Q8NI17-1: amino acid length is 732, molecular weight is 82954 Da (predicted); Q8NI17-2: amino acid length is 764, molecular weight is 86481 Da (predicted); Q8NI17-3: amino acid length is 662, molecular weight is 74876 Da (predicted); Q8NI17-4: amino acid length is 356, molecular weight is 41026 Da (predicted); Q8NI17-5: amino acid length is 681, molecular weight is 77047 Da (predicted); Q8NI17-6: amino acid length is 622, molecular weight is 70363 Da (predicted); Q8NI17-7: amino acid length is 509, molecular weight is 58390 Da (predicted); Q8NI17-8: amino acid length is 582, molecular weight is 66605 Da (predicted); Q8NI17-9: amino acid length is 560, molecular weight is 63638 Da (predicted); Q8NI17-10: amino acid length is 611, molecular weight is 69491 Da (predicted); Q8NI17-11: amino acid length is 626, molecular weight is 71023 Da (predicted); Q8NI17-12: amino acid length is 745, molecular weight is 84309 Da (predicted).N-glycosylated
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Subunit
Interacts with JAK1 and STAT3
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SwissProt ID
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Synonyms
CRL3, GPL, UNQ6368/PRO21073/PRO21384, IL31RA, Interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, Cytokine receptor-like 3, GLM-R, Gp130-like monocyte receptor, ZcytoR17, hGLM-R, Gp130-like receptor
Documentation
[1]. Dillon SR, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004 Jul;5(7):752-60. [Content Brief]
[2]. Dreuw A, et al. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J Biol Chem. 2004 Aug 20;279(34):36112-20. [Content Brief]
[3]. Diveu C, et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur Cytokine Netw. 2004 Oct-Dec;15(4):291-302. [Content Brief]
[4]. Ghilardi N, et al. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. J Biol Chem. 2002 May 10;277(19):16831-6. [Content Brief]
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